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August 26, 2020

Selective Sensing of Cr 2 O 72- and Prevention Activity

By Ivan

A New Luminescent Zn(II) Complex: Selective Sensing of Cr 2 O 72- and Prevention Activity Against Orthodontic Root Absorption by Suppressing Inflammatory Response

A novel luminescent coordination polymer (CP) based on Zn(II) ions as nodes [Zn(OPY)1.5(Hbtc)]n (1), [H3btc = trimesic acid and OPY = 4,4′-(oxybis(4,1-phenylene))dipyridine] has been prepared via the solvothermal assembly of a tripodal multicarboxylic acid ligand, a bis-pyridyl ligand with V-shape containing two diverse coordination patterns as well as Zn2 + ion.
The experiments of photoluminescence also reflect that the coordination polymer 1 has high sensitivity to potassium dichromate, and its quenching efficiency is Ksv of 2.12 × 104 L·mol– 1.
Furthermore, its treatment activity on orthodontic root absorption was evaluated in vivo. Firstly, the CCK-8 assay was performed in this research to evaluate the biotoxicity of the synthetic compound. Next, the TNF-α and Cbfα1 released by the periodontal ligament fibroblast was determined via the ELISA test kit.
In addition to this, the signaling pathway of NF-κB activation after treated with compound was measured by the RT-PCR.
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8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
DLR-8-OHdG-Ge-96T 96T
EUR 608.00
  • Should the 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of 8-Hydroxydeoxyguanosine (8-OHdG) in samples from serum, plasma or other biological fluids.

8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
DL-8-OHdG-Ge-192 1 kit of 192 tests
EUR 1028.00
Description: An ELISA kit based on the competitive inhibition method for detection and quantification of 8-Hydroxydeoxyguanosine (8-OHdG)

8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
DL-8-OHdG-Ge-48 1 kit of 48 tests
EUR 439.00
Description: An ELISA kit based on the competitive inhibition method for detection and quantification of 8-Hydroxydeoxyguanosine (8-OHdG)

8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
DL-8-OHdG-Ge-96 1 kit of 96 tests
EUR 584.00
Description: An ELISA kit based on the competitive inhibition method for detection and quantification of 8-Hydroxydeoxyguanosine (8-OHdG)

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
RDR-8-OHdG-Ge-48Tests 48 Tests
EUR 488.00

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
RDR-8-OHdG-Ge-96Tests 96 Tests
EUR 676.00

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
RD-8-OHdG-Ge-48Tests 48 Tests
EUR 467.00

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
RD-8-OHdG-Ge-96Tests 96 Tests
EUR 646.00

EpiQuik 8-OHdG DNA Damage Quantification Direct Kit (Colorimetric)
P-6003 96 Assays
EUR 947.55
Description: fast delivery possible

EpiQuik 8-OHdG DNA Damage Quantification Direct Kit (Fluorometric)
P-6004 96 Assays
EUR 1034.55
Description: reagents widely cited

OxiSelect Oxidative DNA Damage ELISA Kit (8-OHdG Quantitation) (1 plate)
STA-320 96 assays
EUR 960.00
Description: Among numerous types of oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG) is a ubiquitous marker of oxidative stress. 8-OHdG, one of the byproducts of oxidative DNA damage, is physiologically formed and enhanced by chemical carcinogens. Our OxiSelect Oxidative DNA Damage ELISA Kit (8-hydroxydeoxyguanosine assay) provides a powerful method for rapid, sensitive quantitation of 8-OHdG in DNA samples.

OxiSelect Oxidative DNA Damage ELISA Kit (8-OHdG Quantitation) (5 plates)
STA-320-5 5 x 96 assays
EUR 3953.00
Description: Among numerous types of oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG) is a ubiquitous marker of oxidative stress. 8-OHdG, one of the byproducts of oxidative DNA damage, is physiologically formed and enhanced by chemical carcinogens. Our OxiSelect Oxidative DNA Damage ELISA Kit (8-hydroxydeoxyguanosine assay) provides a powerful method for rapid, sensitive quantitation of 8-OHdG in DNA samples.

OxiSelect Oxidative DNA Damage ELISA Kit (8-OHdG Quantitation), Trial Size
STA-320-T 32 assays
EUR 508.00
Description: Among numerous types of oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG) is a ubiquitous marker of oxidative stress. 8-OHdG, one of the byproducts of oxidative DNA damage, is physiologically formed and enhanced by chemical carcinogens. Our OxiSelect Oxidative DNA Damage ELISA Kit (8-hydroxydeoxyguanosine assay) provides a powerful method for rapid, sensitive quantitation of 8-OHdG in DNA samples.

8-OHdG(8-Hydroxydeoxyguanosine) ELISA Kit
E-EL-0028-192 192 tests
EUR 580.00
  • No significant cross-reactivity with analogues from other species was determined. Please, note that the data on cross-reactivity is limited. Other samples, aside from the tested ones, may be suitable to be used with this kit.
Description: This ELISA kit uses the Competitive-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with 8-OHdG. During the reaction, 8-OHdG in the sample or standard competes with a fixed amount of 8-OHdG on the solid phase supporter for sites on the Biotinylated Detection Ab specific to 8-OHdG. Excess conjugate and unbound sample or standard are washed from the plate, and Avidin conjugated to Horseradish Peroxidase (HRP) are added to each microplate well and incubated. Then a TMB substrate solution is added to each well. The enzyme-substrate reaction is terminated by the addition of stop solution and the color change is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The concentration of 8-OHdG in the samples is then determined by comparing the OD of the samples to the standard curve.

8-OHdG(8-Hydroxydeoxyguanosine) ELISA Kit
E-EL-0028-96 96 tests
EUR 367.00
  • No significant cross-reactivity with analogues from other species was determined. Please, note that the data on cross-reactivity is limited. Other samples, aside from the tested ones, may be suitable to be used with this kit.
Description: This ELISA kit uses the Competitive-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with 8-OHdG. During the reaction, 8-OHdG in the sample or standard competes with a fixed amount of 8-OHdG on the solid phase supporter for sites on the Biotinylated Detection Ab specific to 8-OHdG. Excess conjugate and unbound sample or standard are washed from the plate, and Avidin conjugated to Horseradish Peroxidase (HRP) are added to each microplate well and incubated. Then a TMB substrate solution is added to each well. The enzyme-substrate reaction is terminated by the addition of stop solution and the color change is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The concentration of 8-OHdG in the samples is then determined by comparing the OD of the samples to the standard curve.

8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
abx257146-96tests 96 tests
EUR 668.00
  • Shipped within 5-12 working days.

8-OHdG(8-Hydroxydeoxyguanosine) ELISA Kit
EU2548 96T
EUR 476.25
  • Detection range: 1.563-100 ng/ml
  • Alias: 8-OHdG(8-Hydroxydeoxyguanosine)/8-oxo-DG/ 8-hydroxy-2 deoxyguanosine
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: General;Sensitivity: 0.938 ng/ml

Porcine 8-OHdG ELISA Kit
EPA0694 96Tests
EUR 521.00

Porcine 8-OHdG ELISA Kit
EPH0014 96Tests
EUR 521.00

Mouse 8-OHdG ELISA Kit
EMA0694 96Tests
EUR 521.00

Mouse 8-OHdG ELISA Kit
EMH0014 96Tests
EUR 521.00

Monkey 8-OHdG ELISA Kit
EMKH0014 96Tests
EUR 521.00

Rat 8-OHdG ELISA Kit
ERA0694 96Tests
EUR 521.00

Rat 8-OHdG ELISA Kit
ERH0014 96Tests
EUR 521.00

Rabbit 8-OHdG ELISA Kit
ERTA0694 96Tests
EUR 521.00

Rabbit 8-OHdG ELISA Kit
ERTH0014 96Tests
EUR 521.00

Human 8-OHdG ELISA Kit
EHA0694 96Tests
EUR 521.00

Human 8-OHdG ELISA Kit
EHH0014 96Tests
EUR 521.00

Goat 8-OHdG ELISA Kit
EGTA0694 96Tests
EUR 521.00

Goat 8-OHdG ELISA Kit
EGTH0014 96Tests
EUR 521.00

Anserini 8-OHdG ELISA Kit
EAA0694 96Tests
EUR 521.00

Bovine 8-OHdG ELISA Kit
EBA0694 96Tests
EUR 521.00

Bovine 8-OHdG ELISA Kit
EBH0014 96Tests
EUR 521.00

Canine 8-OHdG ELISA Kit
ECA0694 96Tests
EUR 521.00

Chicken 8-OHdG ELISA Kit
ECKH0014 96Tests
EUR 521.00

ELISA kit for 8-OHdG (8-Hydroxydeoxyguanosine)
E-EL-0028 1 plate of 96 wells
EUR 377.00
  • Gentaur's 8-OHdG ELISA kit utilizes the Competitive-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with 8-OHdG. During the reaction, 8-OHdG in the sample or standard competes with a fixed amount of 8-OHdG on the solid
  • Show more
Description: A competitive ELISA kit for quantitative measurement of 8-OHdG (8-Hydroxydeoxyguanosine) in samples from Serum, Plasma, Cell supernatant

Human 8-Hydroxydeoxyguanosine (8-OHdG) ELISA kit
CSB-E10140h-24T 1 plate of 24 wells
EUR 165.00
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativecompetitive ELISA kit for measuring Human 8-Hydroxydeoxyguanosine (8-OHdG) in samples from serum, urine, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human 8-Hydroxydeoxyguanosine (8-OHdG) ELISA kit
1-CSB-E10140h
  • EUR 900.00
  • EUR 5476.00
  • EUR 2900.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativecompetitive ELISA kit for measuring Human 8-Hydroxydeoxyguanosine (8-OHdG) in samples from serum, urine, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
CEA660Ge-10x96wellstestplate 10x96-wells test plate
EUR 5359.82
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of General 8-Hydroxydeoxyguanosine (8-OHdG) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: C
  • Show more
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General 8-Hydroxydeoxyguanosine (8-OHdG) in serum, plasma and other biological fluids.

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
CEA660Ge-1x48wellstestplate 1x48-wells test plate
EUR 529.04
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of General 8-Hydroxydeoxyguanosine (8-OHdG) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: C
  • Show more
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General 8-Hydroxydeoxyguanosine (8-OHdG) in serum, plasma and other biological fluids.

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
CEA660Ge-1x96wellstestplate 1x96-wells test plate
EUR 712.92
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of General 8-Hydroxydeoxyguanosine (8-OHdG) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: C
  • Show more
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General 8-Hydroxydeoxyguanosine (8-OHdG) in serum, plasma and other biological fluids.

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
CEA660Ge-5x96wellstestplate 5x96-wells test plate
EUR 2908.14
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of General 8-Hydroxydeoxyguanosine (8-OHdG) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: C
  • Show more
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General 8-Hydroxydeoxyguanosine (8-OHdG) in serum, plasma and other biological fluids.

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
4-CEA660Ge
  • EUR 5410.00
  • EUR 2859.00
  • EUR 713.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
  • Known also as 8-Hydroxydeoxyguanosine elisa. Alternative names of the recognized antigen: 8OHdG
  • 7, 8-Dihydro-8-Oxo-2'-Deoxyguanosine
  • 7, 8-Dihydro-8-Oxodeoxyguanosine
  • 8-Hydroxy-2'-Deoxyguanosine
  • 8-Oxo-DG
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of General 8-Hydroxydeoxyguanosine (8-OHdG) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species.

Rat 8-OHdG(8-Hydroxydeoxyguanosine) ELISA Kit
ER1487 96T
EUR 524.10
  • Detection range: 1.563-100 ng/ml
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Rattus;Sensitivity: 0.938 ng/ml

General 8-Hydroxydeoxyguanosine ELISA Kit (8-OHdG)
RK00610 96 Tests
EUR 521.00

8-OHdG antibody
20R-3019 200 ul
EUR 879.00
Description: Goat polyclonal 8-OHdG antibody

8-OHdG antibody
20R-HG001 250 ul
EUR 404.00
Description: Goat polyclonal 8-OHdG antibody

8-Hydroxydeoxyguanosine (8-OHdG) CLIA Kit
20-abx490203
  • EUR 8835.00
  • EUR 4701.00
  • EUR 1083.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Shipped within 5-20 working days.

8-Hydroxydeoxyguanosine (8-OHdG) CLIA Kit
abx195023-96tests 96 tests
EUR 825.00
  • Shipped within 5-12 working days.

8-OHdG ELISA Kit| General 8-Hydroxydeoxyguanosine ELISA Kit
EF019575 96 Tests
EUR 689.00

New 8-OHdG Check ELISA kit
KOG-200SE
EUR 517.00

QuickDetect? 8-OHdG (Mouse) ELISA Kit
E4441-100
EUR 588.00

QuickDetect? 8-OHdG (Rat) ELISA Kit
E4442-100
EUR 588.00

Guinea Pig 8-OHdG ELISA Kit
EGA0694 96Tests
EUR 521.00

Guinea Pig 8-OHdG ELISA Kit
EGH0014 96Tests
EUR 521.00

New 8-OHdG Check ELISA kit
LF-EK90002 1x96T
EUR 975.00

8-Hydroxy-2' -Deoxyguanosine (8-OHdG) ELISA Kit
abx575816-96tests 96 tests
EUR 668.00
  • Shipped within 5-12 working days.

Rat 8-Hydroxy-desoxyguanosine, 8-OHdG ELISA Kit
CSB-E10526r-24T 1 plate of 24 wells
EUR 165.00
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Rat 8-Hydroxy-desoxyguanosine, 8-OHdG in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat 8-Hydroxy-desoxyguanosine, 8-OHdG ELISA Kit
1-CSB-E10526r
  • EUR 967.00
  • EUR 5925.00
  • EUR 3134.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Rat 8-Hydroxy-desoxyguanosine, 8-OHdG in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse 8-Hydroxy-desoxyguanosine, 8-OHdG ELISA Kit
CSB-E10527m-24T 1 plate of 24 wells
EUR 165.00
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativecompetitive ELISA kit for measuring Mouse 8-Hydroxy-desoxyguanosine, 8-OHdG in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse 8-Hydroxy-desoxyguanosine, 8-OHdG ELISA Kit
1-CSB-E10527m
  • EUR 946.00
  • EUR 5782.00
  • EUR 3060.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativecompetitive ELISA kit for measuring Mouse 8-Hydroxy-desoxyguanosine, 8-OHdG in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human 8-Hydroxy-desoxyguanosine,8-OHdG ELISA Kit
201-12-1437 96 tests
EUR 440.00
  • This 8-Hydroxy-desoxyguanosine ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

8-Hydroxy-2' -Deoxyguanosine (8-OHdG) ELISA Kit
20-abx150312
  • EUR 7504.00
  • EUR 3996.00
  • EUR 926.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Shipped within 5-7 working days.

Rat 8-Hydroxy-desoxyguanosine,8-OHdG ELISA Kit
CN-01631R1 96T
EUR 447.00

Rat 8-Hydroxy-desoxyguanosine,8-OHdG ELISA Kit
CN-01631R2 48T
EUR 296.00

Mouse 8-Hydroxy-desoxyguanosine,8-OHdG ELISA Kit
CN-02504M1 96T
EUR 471.00

Mouse 8-Hydroxy-desoxyguanosine,8-OHdG ELISA Kit
CN-02504M2 48T
EUR 322.00

Human 8-Hydroxy-desoxyguanosine,8-OHdG ELISA Kit
CN-03486H1 96T
EUR 457.00

Human 8-Hydroxy-desoxyguanosine,8-OHdG ELISA Kit
CN-03486H2 48T
EUR 313.00

Human 8-Hydroxy-desoxyguanosine(8-OHdG)ELISA Kit
GA-E1453HM-48T 48T
EUR 289.00

Human 8-Hydroxy-desoxyguanosine(8-OHdG)ELISA Kit
GA-E1453HM-96T 96T
EUR 466.00

Mouse 8-Hydroxy-desoxyguanosine(8-OHdG)ELISA Kit
GA-E0200MS-48T 48T
EUR 336.00

Mouse 8-Hydroxy-desoxyguanosine(8-OHdG)ELISA Kit
GA-E0200MS-96T 96T
EUR 534.00

Rat 8-Hydroxy-desoxyguanosine(8-OHdG)ELISA Kit
GA-E0008RT-48T 48T
EUR 317.00

Rat 8-Hydroxy-desoxyguanosine(8-OHdG)ELISA Kit
GA-E0008RT-96T 96T
EUR 496.00

Porcine 8-Hydroxy-desoxyguanosine,8-OHdG ELISA Kit
GA-E0031PC-48T 48T
EUR 364.00

Brain-derived neurotrophic factor and nerve growth factor concentrations in maternal and umbilical cord blood of opium addicted mothers

Background: It is reported that opium consumption during pregnancy is associated with adverse pregnancy outcomes and neurodevelopmental defects in infants. BDNF and NGF alterations during pregnancy cause neurobehavioral deficits in the offspring. The aim of this study was to investigate the effect of opium addiction of pregnant women on BDNF and NGF levels in maternal and umbilical cord blood as well as pregnancy outcome.
Materials and methods: The present research was a cross-sectional study. Thirty-five addicted pregnant women and thirty-five healthy pregnant women were included in the study. Blood samples were taken immediately after delivery from the maternal vein and umbilical cord. Then, BDNF and NGF concentrations in serum were measured by ELISA kits. The outcomes of pregnancy were determined by a checklist. Descriptive, T-test, Mann-Whitney, and Chi-square test were used to analyze the data. SPSS version 21 software was used for the analyses. A p-value <0.05 was considered significant.
Results:  BDNF levels were significantly lower in maternal and umbilical cord blood in the opium-addicted group (917.2 31 ± 316.5 pg/ml and 784.6 ± 242.9 pg/ml respectively) compared to the control group (1351 ± 375 pg/ml and 1063 ± 341 pg/ml respectively) (p<0.0001and p< 0.0002 respectively). Similarly, NGF level was significantly lower in maternal and umbilical cord blood in the opium-addicted group (302.7±35.50 pg/ml and 226.6±45.43 pg/ml respectively) compared to the control group (345.7±43.16 pg/ml and 251.2±37.72 pg/ml respectively) (p<0.0001and p= 0.0165 respectively). Adverse pregnancy outcomes such as NICU admissions, congenital anomalies, neonatal deaths, meconium contaminated amniotic fluid, respiratory problems, neonatal resuscitation, and low Apgar score were significantly higher in the opium-addicted group than in the control group.
Conclusion: The results of this study revealed that opium consumption during pregnancy reduces BDNF and NGF levels in maternal and umbilical cord blood, which may cause neurodevelopmental disorders in later periods of infants’ life.

Potential role of CFTR in bisphenol A-induced malignant transformation of prostate cells via mitochondrial apoptosis

Bisphenol A (BPA) is an environmental endocrine disruptor and a risk factor for prostate cancer. The cystic fibrosis transmembrane conductance regulator (CFTR) is proposed to be a prostate cancer suppressor in some recent researches.
  • However, the potential role and mechanism of CFTR in BPA-induced prostate cancer cells has not been well identified. In this study, BPA decreased the viability of human normal prostate RWPE-1 cells detected with a CCK-8 kit.
  • The capacity of the cell line on soft agar colony formation, wound healing, and transwell invasion indicated malignant transformation induced by BPA. Western blot analysis demonstrated that the levels of CFTR and Bcl-2 decreased, whereas Bax level increased, and ELISA detection showed a decreased ATP level in BPA-exposed cells. Cell apoptosis was analyzed with Annexin V-FITC Detection Kit by flow cytometry.
  • However, no significant difference was observed in cell viability and apoptosis rates compared to normal RWPE-1 cells. Our research revealed a potential role of CFTR in BPA-induced malignant transformation via mitochondrial apoptosis of normal prostate cells.

 

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